8/9/2023 0 Comments Detectx pro![]() A greater than 20% total body surface area (TBSA) full-thickness burn injury stimulates hypermetabolism in humans. ![]() The systemic hypermetabolic response refers to a significant increase in the resting energy expenditure, which is largely driven by elevated levels of circulating catecholamines, glucocorticoids and pro-inflammatory cytokines following burn injury. In contrast to simple cutaneous wounds, major burn injury simultaneously also triggers a systemic pathophysiological stress response and hypermetabolism. This involves the four complex and overlapping phases of haemostasis, inflammation, proliferation and remodelling. In conclusion, DHT treatment facilitates local wound healing by accelerating the resolution of inflammation, but not through alterations of post-burn hypermetabolic response.īoth cutaneous (non-burn) and burn injuries immediately trigger the local wound healing process. ![]() DHT treatment also reduced wound infiltrating macrophage numbers. DHT treatment shortened the systemic inflammatory response with reduced splenic weight and monocyte numbers on day 14 and 21. Mice, after burn injury, displayed acute systemic inflammatory responses over 21 days. In results, DHT treated mice lost less weight and displayed accelerated wound healing but has no impact on hypermetabolism. Healing phases of inflammation, re-epithelialization, cell proliferation and collagen deposition were also examined. In addition, splenocyte enumeration was performed by flow cytometry. The serum level of inflammatory cytokines/chemokines were measured using multiplex immunoassays. Wound healing rate and body weight were monitored over 21 days. In the present study, mice received systemic androgen treatment post major burn injury. The aim of this study is to investigate the role of dihydrotestosterone (DHT) as a new therapeutic approach in treating major burn injury. However, in children with major burn injuries, a synthetic androgen was reported clinically to improve wound healing. Androgens have been known to inhibit cutaneous wound healing in men and male mice.
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